Profile of malignant hyperthermia susceptibility reports confirmed with muscular contracture test in Brazil
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چکیده
منابع مشابه
Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil.
Malignant hyperthermia (MH) is a pharmacogenetic disease triggered by volatile anesthetics and succinylcholine. Deaths due to MH have been reported in Brazil. The first Malignant Hyperthermia Diagnostic and Research Center in Latin America was inaugurated in 1993 at the Federal University of Rio de Janeiro, Brazil. The center followed the diagnostic protocols of the North America MH Group, in w...
متن کاملReproducibility of in vitro contracture test results in patients tested for malignant hyperthermia susceptibility.
BACKGROUND The in vitro contracture test (IVCT) is the golden standard to diagnose malignant hyperthermia susceptibility (MHS). A high reproducibility is important for a high validity of a test. METHODS We have therefore analyzed IVCT in 838 patients, investigated in two laboratories. Each halothane and caffeine test was performed in two muscle strips. The test results were analyzed with resp...
متن کاملContractile elements in muscular fascial tissue - implications for in-vitro contracture testing for malignant hyperthermia.
Malignant hyperthermia is a dreaded complication of general anaesthesia. Predisposed individuals can be identified using the standardised caffeine/halothane in-vitro contracture test on a surgically dissected skeletal muscle specimen. Skeletal muscle is composed of muscle fibres and interwoven fascial components. Several malignant hyperthermia-associated neuromuscular diseases are associated wi...
متن کاملMalignant hyperthermia and muscular dystrophies.
BACKGROUND Patients with muscular dystrophy have been reported to experience a variety of life-threatening complications during and after general anesthesia. We performed a systematic analysis to define the spectrum of anesthetic-related complications in patients with muscular dystrophy, with an emphasis on malignant hyperthermia susceptibility. METHODS A literature search was undertaken usin...
متن کاملMalignant Hyperthermia
''Malignant Hypothermia'' syndrome is a rare, but dangerous occurrence, the aetiology of which is not known. Up to this date 180 cases have been reported. This syndrome i's seen generally in :male children over age of two years, and especially in adolescent males. Also those people with muscular abnormalities are more susciptable to this illnes'S. Anaesthetic agent such as halothane or muscular...
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ژورنال
عنوان ژورنال: Brazilian Journal of Anesthesiology (English Edition)
سال: 2019
ISSN: 0104-0014
DOI: 10.1016/j.bjane.2018.09.009